Floating microspheres: Emerging delivery system for diabetes mellitus

In order to increase bioavailability, stability, and target the drug a specific region at predetermined rate, floating microspheres, multi-unit delivery systems, are designed accomplish controlled or delayed administration. clinical practise, drugs that have an upper small intestine absorption window may benefit most from system with extended stomach residence period. The non-uniformity of medication throughout gastrointestinal tract heterogeneity (GI) transit time across among subjects two key issues. common systems in these applications hydrodynamically controlled. Gastro retentive is method extending length gastric residency because it targets site-specific release for local systemic effects (GIT). Due uniform distribution multiple-unit dose forms stomach, which encourages more repeatable medicine lower risk discomfort, microspheres becoming popular. Compared single-unit dosing variants, offer benefits. physiology emptying briefly examined context this paper. This review's objective compile recent research on preparation techniques other factors affect functionality characterization microspheres.